Compositions and methods for l-nucleosides, l-nucleotides,...

Details Compositions and methods for l-nucleosides, l-nucleotides,... Compositions and methods for l-nucleosides, l-nucleotides,...

A - Human Necessities

01

N

A01N 43/04 (2006.01) A01N 43/72 (2006.01) A61K 31/70 (2006.01) A61K 31/7056 (2006.01) A61K 39/395 (2006.01) C07H 19/00 (2006.01) C07H 19/04 (2006.01) C07H 19/044 (2006.01) C07H 19/12 (2006.01)

Patent

CA 2384326

Nucleoside and nucleotide compounds and their analogs/prodrugs are provided. Particularly contemplated compounds include 1-.beta.-L-ribofuranosyl-1,2,4- triazole-3-carboxamide, which may be modified and/or phosphorylated. Contemplated compounds may further be combined with other pharmacological compounds, especially including Ribavirin, antibodies, and cytokines. Preferred uses of contemplated compounds include use as an antiviral compound, anti-inflammatory compound, antineoplastic compound, and as a compound to stimulate cellular growth.

Cette invention a trait à des composés nucléosidiques et nucléotidiques ainsi qu'à leurs analogues/promédicaments. Parmi les composés étudiés figure le 1-.beta.-L-ribofuranosyl-1,2,4-triazole-3-carboxamide, pouvant avoir été modifié et/ou phosphorylé. Ces composés, peuvent, de plus, être combinés avec d'autre composés à usage pharmaceutique, notamment la Ribavirine, des anticorps et des cytokines. Parmi les utilisations préférées de ces composés, on note une utilisation antivirale, une utilisation anti-inflammatoire, une utilisation anti néoplasique et une utilisation visant à stimuler la croissance cellulaire.

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