Compositions and methods for less immunogenic pr0tein-lip1d...

Details Compositions and methods for less immunogenic pr0tein-lip1d... Compositions and methods for less immunogenic pr0tein-lip1d...

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 35/14 (2006.01) A61K 9/127 (2006.01)

Patent

CA 2613705

The present invention provides compositions and methods for reducing the immunogenicity and increasing the circulating half-life of therapeutic proteins such as Factor VIII. The compositions comprise lipidic structures such as liposomes, micelles and cochleates comprising a negatively charged lipid and polyethylene glycol derivatized phospatidyl ethanolamine.

L'invention concerne des compositions et des procédés qui permettent de réduire l'immunogénicité et de prolonger la demi-vie circulante de protéines thérapeutiques, notamment le Factor VIII. Ces compositions contiennent des structures lipidiques telles que les liposomes, les micelles et les cochléaires, qui comportent un lipide de charge négative, ainsi que l'éthanolamine phospatidyl dérivé de polyéthylèneglycol.

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