Compositions and methods for mediating cell cycle progression

Details Compositions and methods for mediating cell cycle progression Compositions and methods for mediating cell cycle progression

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A01H 5/00 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C12N 5/04 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/82 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2242382

Hypercellular nonhuman organisms have functionally inactivated expression of a cyclin inhibitor gene, especially p27. The growth rate of nonhuman organisms are increased such that a desired size is attained more quickly than as compared to nonvariant organisms. Inhibitors of the p27 cyclin dependent kinase inhibitor protein or sequences encoding the protein modulate vertebrate cell cycle progression and increase the proportion of dividing cells to non-dividing cells in a population of treated cells. As the proportion of dividing cells Increases, the cell population, e.g., hematopoietic progenitor (stem) cells, is more efficiently used for gene therapy applications. Transgenic animals and plants, and knockout alleles are provided.

Organismes non humains hypercellulaires présentant l'expression inactivée de manière fonctionnelle d'un gène inhibiteur de la cycline, notamment p27. Le rythme de développement des organismes non humains est accru de façon à obtenir plus rapidement une taille désirée comparé aux organismes non variants. Les inhibiteurs de la cycline p27 dépendant de la protéine inhibitrice kinase ou des séquences codant la protéine modulent la progression du cycle cellulaire des vertébrés et augmente la proportion des cellules en voie de division par rapport aux cellules stables dans une population de cellules traitées. Lorsque la population des cellules en voie de division augmente, la population cellulaire, c.-à-d. les cellules (souches) progénitrices hématopoïtiques, est utilisée avec plus d'efficacité dans des applications de thérapie génique. L'invention se rapporte également à des animaux et des plantes transgéniques et à des allèles "knockout".

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