Compositions and methods for modulating ampa...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/53 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 39/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 17/00 (2006.01) C07K 19/00 (2006.01) C12N 9/02 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2662026

The present invention provides AMPAR excitotoxicity mediating polypeptides comprising the GluR2 NT1 -3-2 (Y142-K172) amino acid sequence (SEQ ID NO:1) or the GAPDH(2-2-1-1) (I221-E250)amino acid sequence (SEQ ID NO:2). Also disclosed are nucleotide sequences encoding the polypeptides, methods of inhibiting GAPDH association with the GluR2 subunit or p53. Methods of inhibiting AMPA receptor mediated excitotoxicity using the polypeptides and nucleic acids are also disclosed.

La présente invention concerne des polypeptides induisant l'excitotoxicité AMPAR, comprenant la séquence d'acides aminés GluR2 NT1 -3-2 (Y142-K172) (SEQ ID NO :1) ou la séquence d'acides aminés GAPDH(2-2-11) (I221-E250) (SEQ ID NO :2). L'invention concerne également des séquences de nucléotides codant pour les polypeptides, des procédés d'inhibition de l'association de GAPDH avec la sous-unité GluR2 ou p53. L'invention concerne également des procédés d'inhibition de l'excitotoxicité induite par le récepteur AMPA en utilisant les polypeptides et les acides nucléiques.

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