Compositions and methods for modulating an immune response

Details Compositions and methods for modulating an immune response Compositions and methods for modulating an immune response

A - Human Necessities

61

K

A61K 35/56 (2006.01)

Patent

CA 2632341

The present invention provides a composition for suppressing an inflammatory immune response comprising the excretory / secretory (ES) component of Fasciola hepatica or a fraction thereof. The composition has particular utility in the treatment or prophylaxis of T cell mediated inflammatory immune responses, and in particular autoimmune disease. The invention further extends to methods for modulating a T cell mediated immune response wherein a therapeutically effective amount of the excretory / secretory (ES) component from Fasciola hepatica is administered to a subject in need of such treatment in order to suppress the development of the response.

La présente invention a pour objet une composition destinée à inhiber une réponse immunitaire inflammatoire impliquant les composants d~excrétion/ sécrétoires (ES) de Fasciola hepatica ou une fraction d~entre eux. La composition est particulièrement utile dans le traitement ou la prophylaxie des réponses immunitaires inflammatoires induites par les lymphocytes T, notamment les maladies auto-immunes. L~invention concerne également des procédés de modulation d~une réponse immunitaire induite par les lymphocytes T comportant l~administration d~une quantité efficace thérapeutiquement de composant d~excrétion/ sécrétoire de Fasciola hepatica à un sujet nécessitant un tel traitement pour inhiber le développement de la réponse immunitaire.

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