C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 38/40 (2006.01) A61K 45/06 (2006.01) A61K 47/48 (2006.01) A61P 25/00 (2006.01) C07K 14/705 (2006.01) C07K 14/79 (2006.01) C12N 9/00 (2006.01) C12N 9/24 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2450073
This invention provides conjugates of therapeutic or active agents with melanotransferrin or with other ligands of a melanotransferrin receptor, melanotransferrin receptor modulators, and related compositions and methods for modulating blood-brain barrier transport by providing methods of screening and selecting such conjugates, ligands, and modulators in vitro and in vivo, and methods of use of such conjugates, modulators and ligands in diagnosis and the treatment of diseases, including particularly diseases of the central nervous system or lysosomal storage diseases.
L'invention concerne des conjugués d'agents thérapeutiques ou d'agents actifs avec de la mélanotransferrine ou d'autres ligands d'un récepteur de la mélanotransferrine, des modulateurs des récepteurs de la mélanotransferrine, des compositions associées et des procédés de modulation du transport à travers la barrière hématho-encéphalique mettant en oeuvre des procédés de tri et de sélection desdits conjugués, ligands, et modulateurs in vitro et in vivo, et des méthodes d'utilisation desdits conjugués, modulateurs et ligands dans le diagnostic et dans le traitement de maladies, notamment de maladies du système nerveux central ou de maladies lysosomale
Beliveau Richard
Demeule Michel
Gabathuler Reinhard
Kennard Malcolm L.
Yang Joseph
Biomarin Pharmaceutical Inc.
Kirby Eades Gale Baker
Raptor Pharmaceutical Inc.
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