Compositions and methods for modulating c-kit and pdgfr...

Details Compositions and methods for modulating c-kit and pdgfr... Compositions and methods for modulating c-kit and pdgfr...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01)

Patent

CA 2667010

The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFR , PDGFR , CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGF , SRC, EGFR, trkB, FGFR3, FLT3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2 , BRK, KDR, c-raf or b-raf kinase, or mutant forms thereof.

La présente invention concerne des composés et des compositions pharmaceutiques utiles en tant qu'inhibiteurs de la protéine kinase, ainsi que des procédés d'utilisation de tels composés pour traiter, améliorer ou prévenir une condition associée à une activité anormale ou déréglée des kinases. Selon certains modes de réalisation, l'invention concerne des procédés d'utilisation de tels composés pour traiter, améliorer ou prévenir des maladies ou troubles impliquant l'activation anormale de c-kit, PDGFR , PDGFR , CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGF , SRC, EGFR, trkB, FGFR3, FLT3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2, BRK, KDR, c-raf ou b-raf kinase, ou des formes mutantes de ceux-ci.

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