C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 48/00 (2006.01) C12N 15/85 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2545260
The present invention is directed to compositions and methods for modulating c- Rel-dependent cytokine production without materially altering the level of expression of NF.kappa.B and/or the amount of I.kappa.B. The present invention is also directed to screening for modulators of c-Rel activity as determined by assaying for altered subcellular localization of c-Rel but where the level of expression of NF.kappa.B and/or the amount of I.kappa.B is materially unaltered.
La présente invention concerne des compositions et des procédés visant à moduler la production de cytokines dépendant de c-Rel sans modifier matériellement le niveau d'expression de NF.kappa.B et/ou la quantité de I.kappa.B. La présente invention concerne également le criblage de modulateurs de l'activité de c-Rel telle que déterminée par l'analyse de la localisation infracellulaire modifiée de c-Rel selon lequel le niveau d'expression de NF.kappa.B et/ou la quantité de I.kappa.B reste matériellement inchangé.
Barsoum James
Lu Rongzhen
Wada Yumiko
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Synta Pharmaceuticals Corp.
LandOfFree
Compositions and methods for modulating c-rel-dependent... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for modulating c-rel-dependent..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for modulating c-rel-dependent... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1806001