C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 7/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2281920
Compositions and methods for modulating the activation of nuclear factor .kappa.B (NF-.kappa.B) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated I.kappa.B.alpha. and/or I.kappa.B.beta.. Such compositions may be used for treating diseases associated with NF-.kappa.B activation. Modulating agents include peptides that comprise a recognition domain for E3 ubiquitin ligase.
Compositions et procédés servant à moduler l'activation du facteur nucléaire ?B (NF-?B). Ces compositions contiennent un ou plusieurs agents modulant l'ubiquitination, soit de I?B.alpha., soit de I?B.beta.. On peut utiliser ces compositions afin de traiter des maladies associées à l'activation de NF-?B. Les agents modulants incluent des peptides présentant un domaine de reconnaissance d'ubiquitine ligase de E3.
Alkalay Irit
Ben-Neriah Yinon
Ciechanover Aaron
Manning Anthony
Mercurio Frank
Gowling Lafleur Henderson Llp
Signal Pharmaceuticals Inc.
Signal Pharmaceuticals Llc
Yissum Research Development Company Of The Hebrew University In
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