Compositions and methods for modulating d1-d2 dopamine...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/705 (2006.01) A61K 38/20 (2006.01) A61K 39/395 (2006.01) A61P 25/24 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2727086

The present invention provides for prevention and/or treatment of neurological or neuropsychiatric disorders involving abnormal D1-D2 dopamine receptor coupling and/or activation. Methods and agents are provided for modulating dopamine receptor function arising from D1-D2 coupling and/or activation. Agents of the present invention include fragments of D2 receptor or D1 receptor that can disrupt D1-D2 coupling.

La présente invention concerne la prévention et/ou le traitement de troubles neurologiques ou neuropsychiatriques comprenant un couplage et/ou une activation anormaux du récepteur D1-D2 dopaminergique. L'invention concerne également des procédés et des agents de modulation de la fonction du récepteur dopaminergique résultant du couplage et/ou de l'activation des D1-D2. Les agents de la présente invention comprennent des fragments du récepteur D2 ou du récepteur D1 qui peuvent interrompre le couplage D1-D2.

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