Compositions and methods for modulating dopamine...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/62 (2006.01) A61K 31/7088 (2006.01) C07K 7/00 (2006.01) C07K 14/435 (2006.01) C12N 15/12 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2607095

The present invention provides for diagnosis or treatment of neurological or neuropsyciatric disorders involving abnormal dopamine neurotransmission. Methods and agents are provided for modulating dopamine transporter activity and modulating dopaminergic neurotransmission. Agents of the present invention include fragments of D2 receptor or dopamine transporter (DAT) that can disrupt D2-DAT coupling.

La présente invention porte sur le diagnostic ou le traitement de troubles neurologiques ou neuropsychiatriques impliquant la neurotransmission de la dopamine anormale. L'invention porte également sur des méthodes et sur des agents permettant de moduler l'activité du transporteur de la dopamine et de moduler la neurotransmission dopaminénergique. Les agents de cette invention comprennent des fragments du récepteur D2 ou du transporteur de la dopamine (DAT) qui peuvent rompre le couplage D2-DAT.

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