Compositions and methods for modulating gated ion channels

Details Compositions and methods for modulating gated ion channels Compositions and methods for modulating gated ion channels

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/472 (2006.01) A61K 31/4745 (2006.01)

Patent

CA 2652307

The alleged invention relates to indole derivatives according to formula 1, namely, wherein X is CH2, O, NR2 or NOR2 and wherein A is preferably a six membered ring involving a nitrogen heteroatom. These compounds and their pharmaceutical acceptable salts are used for modulating gated ion channels in order to treat pain, inflammatory disorders, neurological disorders, or diseases associated with the genitourinary or gastrointestinal systems.

Cette invention concerne des dérivés d'indole selon la formule1, dans laquelle X représente, notamment, CH2, O, NR2 ou NOR2 et A représente, de préférence, un cycle à six chaînons impliquant un hétéroatome d'azote. Ces composés et leurs sels pharmaceutiquement acceptables sont utilisés afin de moduler des canaux ioniques commandé en vue de traiter la douleur, les troubles inflammatoires, les troubles neurologiques, ou les maladies associées aux systèmes gastro-intestinal ou génito-urinaire.

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