Compositions and methods for modulating gated ion channels

A - Human Necessities – 61 – K

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Details

A61K 31/4709 (2006.01) A61K 31/49 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2561993

The present application relates to compositions which modulate the activity of gated ion channels. This provide an effect in the treatment of pain, inflammatory disorders and neurological disorders. Preferred compounds include quinine or quinidine derivatives with the hydroxyl at the nine position being esterified with an aliphatic carboxylic acid, optionally bearing an additional cycloalkyl ring on the chain. The gated ion channels modulated include homomultimeric and heteromultimeric gates.

La présente invention concerne des compositions et des méthodes de modulation de l'activité des canaux ioniques commandés par porte.

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