Compositions and methods for modulating gated ion channels

Details Compositions and methods for modulating gated ion channels Compositions and methods for modulating gated ion channels

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4745 (2006.01)

Patent

CA 2630617

Pyrrolo-isoquinoline compounds according to formula (I) wherein R3 is preferably a hydroxy radical and the southern ring is preferably a phenyl ring. These compounds and their pharmaceutical acceptable salts are used for modulating gated ion channels in order to treat pain, inflammatory disorders, neurological disorders, or diseases associated with the genitourinary or gastrointestinal systems.

La présente invention concerne des composés pyrrolo-isoquinoliniques représentés par la formule (I) dans laquelle R3 est de préférence un radical hydroxy, le noyau sud étant de préférence un noyau phényle. Ces composés et leurs sels pharmaceutiquement admis conviennent à la modulation des canaux ioniques dans le cadre d'un traitement de la douleur, de troubles inflammatoires, de troubles neurologiques, ou d'affections associées au système génito-urinaire ou au système gastro-intestinal.

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