C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) C07K 14/705 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2652058
The present invention provides a newly identified CD28 family member that functions as lymphocyte inhibitory receptor termed pG6b, which is expressed on T cells. Methods and compositions for modulating pG6b-mediated negative signaling and interfering with the interaction of its counter-receptor for therapeutic, diagnostic, and research purposes are also provided.
La présente invention concerne un élément de la famille des CD28 nouvellement identifié qui agit en tant que récepteur inhibiteur de lymphocyte. Dénommé pG6b, il est exprimé sur les lymphocytes T. L'invention concerne également des procédés et des compositions permettant de moduler un signal négatif médié par le pG6b et d'interférer avec l'interaction de son contre récepteur à des fins thérapeutiques, diagnostiques et de recherche.
Gao Zeren
Hebb Luanne
Howard Edward D.
Johnston Janet V.
Levin Steven D.
Smart & Biggar
Zymogenetics Inc.
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