Compositions and methods for modulating immune responses

A - Human Necessities – 61 – K

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Details

A61K 9/14 (2006.01) A61K 9/127 (2006.01) A61K 39/00 (2006.01) A61K 39/35 (2006.01) A61P 37/00 (2006.01) A61P 37/02 (2006.01) A61P 37/04 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2702340

This invention discloses methods and compositions for modulating immune responses, which involve particulate delivery of agents to immune cells, wherein the agents comprise an inhibitor of the NF-.kappa.B signaling pathway and an antigen that corresponds to a target antigen. The methods and compositions of the present invention are particularly useful in the treatment or prophylaxis of an undesirable immune response associated with the target antigen, including autoimmune diseases, allergies and transplantation associated diseases.

La présente invention concerne des procédés et des compositions destinés à moduler des réponses immunes, qui impliquent l'administration particulaire d'agents à des cellules immunes, lesdits agents comprenant un inhibiteur de la voie de signalisation NF-?B et un antigène qui correspond à un antigène cible. Les procédés et les compositions de la présente invention sont particulièrement utiles dans le traitement ou la prophylaxie d'une réponse immune indésirable associée à l'antigène cible, incluant les maladies auto-immunes, les allergies et les maladies associées aux transplantations.

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