A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2489803
The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies B7 family member B7x as interacting with BTLA to attenuate lymphocyte activity. Methods and compositions for modulating BTLA-mediated negative signaling and interfering with the interaction of BTLA and B7x for therapeutic, diagnostic and research purposes are also provided.
La présente invention concerne un nouveau récepteur inhibiteur des lymphocytes, dénommé "BTLA", qui s'exprime aussi bien sur les lymphocytes T que sur les lymphocytes B, et qui identifie un élément B7x de la famille B7 comme capable d'interaction avec le BTLA pour atténuer l'activité lymphocytaire. L'invention concerne également des procédés et des compositions permettant, d'une part de moduler la signalisation négative à médiation du BTLA, et d'autre part d'interférer avec l'interaction entre BTLA et B7x à des fins de thérapies, de diagnostics et de recherches.
Allison James P.
Murphy Kenneth M.
Murphy Theresa L.
Watanabe Norihiko
Yang Jianfei
Smart & Biggar
The Regents Of The University Of California
Washington University
LandOfFree
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