A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A01N 37/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01)
Patent
CA 2579093
The present invention provides methods for modulating mitochondrial function, modulating lesion formation in the brain, modulating neurite growth, modulating neuronal degeneration, and treating and preventing neurological diseases or disorders comprising modulating the expression or activity of PGC- l.alpha.. The present invention also provides an animal, e.g., transgenic mouse, in which the PGC-l.alpha. gene is misexpressed. Methods for identifying compounds which are capable of treating or preventing a neurological disease or disorder are also described.
L'invention concerne des procédés de modulation de la fonction mitochondriale, de modulation de la formation de lésions dans le cerveau, de modulation de la croissance du neurite, de modulation de la dégénération neuronale, ainsi que de traitement et de prévention de maladies ou de troubles neurologiques, procédés comprenant la modulation de l'expression ou de l'activité de PGC-1.alpha.. L'invention concerne également un animal, par exemple, une souris transgénique, dans lequel le gène PGC-1.alpha. est mal exprimé. L'invention concerne également des procédés d'identification de composés qui sont capables de traiter ou de prévenir une maladie ou un trouble neurologique.
Lin Jiandie
Spiegelman Bruce M.
Dana-Farber Cancer Institute Inc.
Riches Mckenzie & Herbert Llp
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