A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01)
Patent
CA 2584331
The present invention provides methods for treating lipid-related diseases and dirorders, e.g., hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, cardiovascular disease, obesity, and type II diabetes, and for modulating lipid biosynthesis, lipid transport, plasma triglyceride levels and/or plasma cholesterol levels, by modulating the expression or activity of PGC-1.beta.. Methods for identifying compounds which are capable of treating or preventing a lipid-related disease or disorder are also described.
La présente invention concerne des méthodes destinées à traiter des maladies et des troubles lipidiques tels que l'hyperlipidémie, l'hypertriglycéridémie, l'hypercholestérolémie, la maladie cardiovasculaire, l'obésité et le diabète de type II, et à moduler la biosynthèse des lipides, le transport des lipides, les taux plasmatiques de triglycérides et/ou les taux plasmatiques de cholestérol par modulation de l'expression ou de l'activité de PGC-1.beta.. L'invention concerne également des méthodes destinées à identifier des composés permettant de traiter ou de prévenir une maladie ou un trouble lipidique.
Lin Jiandie
Newgard Christopher B.
Spiegelman Bruce M.
Dana-Farber Cancer Institute Inc.
Lin Jiandie
Newgard Christopher B.
Riches Mckenzie & Herbert Llp
Spiegelman Bruce M.
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