Compositions and methods for modulating rna activity through...

Details Compositions and methods for modulating rna activity through... Compositions and methods for modulating rna activity through...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2083377

Methods for achieving therapeutic treatment of diseases and for regulating gene expression in biological experimental sys- tems via modification or removal of the 5' Cap stricture of targeted ribonucleic acids are disclosed. Modification or removal of the 5' Cap structure is achieved in accordance with preferred embodiments utilizing antisense compounds which are complemen- tary to the 5' terminus of the targeted RNA and have attached to them reactive moieties explicitly designed for chemical modifi- cation of or cleavage reactions with the 5' Cap structure of RNA.

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