A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/44 (2006.01) A01K 67/00 (2006.01) A61K 31/198 (2006.01) C12Q 1/32 (2006.01) G01N 33/563 (2006.01)
Patent
CA 2528155
Disclosed herein are methods and compositions for modulating the levels and/or activity of S-nitrosoglutathione reductase (GSNOR) in vivo or in vitro. Specifically disclosed are GSNOR deletion constructs, host cells and non-human mammals comprising GSNOR deletions, and methods of screening employing GSNOR deletion mutants. Also specifically disclosed are reagents and procedures for measuring, monitoring, or altering GSNOR levels or activity (as well as nitric oxide and S-nitrosothiol levels) in connection with various medical conditions.
L'invention concerne des procédés et des compositions permettant de moduler les taux et/ou l'activité de S-nitrosoglutathion réductase (GSNOR) in vivo ou in vitro. L'invention se réfère spécifiquement à des gènes chimères comportant une délétion de GSNOR, à des cellules hôtes et à des mammfières non humains comprenant des délétions de GSNOR, et à des procédés de criblage utilisant des mutants comportant une délétion de GSNOR. L'invention concerne aussi spécifiquement des réactifs et des procédures permettant de mesurer, de surveiller ou de modifier les taux ou l'activité de GSNOR (ainsi que les taux d'oxyde nitrique et de S-nitrosothiol) en relation avec divers états pathologiques.
Limin Lin
Stamler Jonathan S.
Duke University
Osler Hoskin & Harcourt Llp
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