C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/074 (2010.01) C12N 5/071 (2010.01) C12N 5/077 (2010.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 21/00 (2006.01) C07K 14/47 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2760042
There are provided compositions and methods for modulating stem cell division decisions, in particular, division symmetry. It has been demonstrated that wnt7a acts through frizzled-7 receptor expressed on the surface of adult stem cells, e.g. satellite stem cells, to activate the planar cell polarity (PCP) pathway, thereby promoting symmetrical expansion of stem cells. The compositions and methods of the invention are useful, for example, in modulating stem cell division symmetry in vitro and in vivo, in replenishing and expanding the stem cell pool, and in promoting the formation, maintenance, repair and regeneration of tissue.
La présente invention concerne des compositions et des méthodes permettant de moduler les décisions de division des cellules souches, en particulier, la symétrie de division. Il a été démontré que wnt7a agit par l'intermédiaire du récepteur Frizzled-7 exprimé à la surface des cellules souches adultes, par exemple, des cellules souches satellites, pour activer la voie de la polarité cellulaire planaire (PCP), favorisant de cette manière l'expansion symétrique des cellules souches. Les compositions et les méthodes de l'invention sont utiles, par exemple, dans la modulation de la symétrie de la division des cellules souches in vitro et in vivo, en réalimentant et en développant le groupe des cellules souches et en favorisant la formation, le maintien, la réparation et la régénération du tissu.
Le Grand Fabien
Rudnicki Michael A.
Borden Ladner Gervais Llp
Ottawa Hospital Research Institute
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