C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) A61P 37/06 (2006.01) A61K 31/7088 (2006.01) C07K 14/705 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2665592
Methods and compositions for modulating neural cell function using antagonists of TLR14 are disclosed. In particular, methods for treating, preventing and/or diagnosing TLR14-associated neurodegenerative conditions and/or disorders are disclosed. Screening methods for evaluating TLR14 modulators, e.g., agonists and antagonists, are also disclosed.
La présente invention concerne des procédés et compositions pour moduler la fonction de cellules neurale au moyen d'antagonistes du TLR14. L'invention concerne plus particulièrement des procédés pour traiter, prévenir et/ou diagnostiquer des états et/ou troubles neurodégénératifs associés au TLR 14. L'invention concerne également des procédés de recherche systématique pour l'évaluation de modulateurs du TLR14 tels que des agonistes et des antagonistes.
Dunne Aisling
Gao Ying
Lin Lih-Ling
Mccormack William John
Seidl Katherine
Opsona Therapeutics Ltd.
Torys Llp
Wyeth
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