Compositions and methods for modulating vascularization

Details Compositions and methods for modulating vascularization Compositions and methods for modulating vascularization

A - Human Necessities

61

K

A61K 35/12 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 38/22 (2006.01) A61K 38/30 (2006.01) A61K 38/44 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61P 9/10 (2006.01) C12Q 1/00 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2322559

The present invention generally provides methods for modulating formation of new blood vessels. In one embodiment, the methods include administering to a mammal an effective amount of granulocyte macrophage-colony stimulating factor (GM-CSF) sufficient to form the new blood vessels. Additionally provided are methods for preventing or reducing the severity of blood vessel damage in a mammal which methods preferably include administering to the mammal an effective amount of GM-CSF. Provided also as part of this invention are pharmaceutical products and kits for inducing formation of new blood vessels in the mammal.

L'invention porte sur des procédés modulant la formation de nouveaux vaisseaux sanguins. Dans l'une des exécutions, les procédés consistent à administrer à un mammifère une dose efficace de GM-CST (sargramostim) suffisante pour former de nouveaux vaisseaux sanguins. L'invention porte en outre sur des procédés prévenant ou réduisant la sévérité des lésions des vaisseaux sanguins d'un mammifère consistant de préférence à lui administrer une dose efficace de GM-CST, ainsi que sur des produits pharmaceutiques et des trousses induisant la formation de vaisseaux sanguins chez les mammifères.

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