Compositions and methods for multimodal imaging

Details Compositions and methods for multimodal imaging Compositions and methods for multimodal imaging

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61B 5/055 (2006.01) A61B 6/00 (2006.01) A61B 8/00 (2006.01) A61K 9/127 (2006.01) A61K 51/00 (2006.01)

Patent

CA 2596595

Provided are signal modifying compositions for medical imaging comprising a carrier and two or more signal modifying agents specific for two or more imaging modalities. The compositions are characterized by retention efficiency, with respect to the signal modifying agents, which enables prolonged contrast imaging without significant depletion of the signal modifying agents from the carrier. The carriers of the present invention are lipid based or polymer based, the physico-chemical properties of which can be modified to entrap or chelate different signal modifying agents and mixtures thereof and to target specific organs or tumors or tissues within a mammal.

L'invention concerne des compositions modificatrices de signal destinées à l'imagerie médicale, qui comprennent un support et deux ou davantage d'agents modificateurs de signal, spécifiques de deux ou davantage de modalités d'imagerie. Les compositions sont caractérisées par leur efficacité de retenue à l'égard des agents modificateurs de signal, qui permet de mettre en oeuvre une imagerie de contraste prolongée sans affaiblissement important desdits agents dans le support. Les supports de l'invention sont lipidiques ou polymères, et leurs propriétés physico-chimiques peuvent être modifiées afin de piéger ou de se lier fortement à différents agents modificateurs de signal et à des mélanges de ceux-ci, et de cibler des organes, tumeurs ou tissus spécifiques chez un mammifère.

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