A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/39 (2006.01) A61L 27/00 (2006.01) A61L 27/36 (2006.01) A61F 2/00 (2006.01) A61F 2/10 (2006.01)
Patent
CA 2223892
The present invention discloses compositions containing naturally secreted human extracellular matricies, the methods of making those matricies, and the method of using those matricies. The extracellular matrix is obtained by growing cells into a three-dimensional support structure so that the cells secrete an extracellular matrix. Next, the cells are killed and removed from the support structure leaving only the extracellular matrix on the support structure. The extracellular matrix can then be removed from the support, combined with a suitable pharmacologically acceptable carrier and injected into a tissue defect area in the skin of a patient.
L'invention concerne des compositions contenant des matrices extracellulaires humaines sécrétées naturellement, leurs procédés de fabrication et d'utilisation. On obtient une matrice extracellulaire selon l'invention en mettant des cellules en culture dans une structure de support tridimensionnelle de sorte que ces dernières sécrètent une matrice extracellulaire. On tue ensuite les cellules et on les retire de la structure de support pour n'y laisser que la matrice extracellulaire, après quoi on peut enlever cette dernière du support, la combiner avec un véhicule approprié pharmacologiquement acceptable et l'injecter dans une zone tissulaire anormale de la peau d'un patient.
Advanced Tissue Sciences Inc.
Osler Hoskin & Harcourt Llp
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