Compositions and methods for oxalate reduction

A - Human Necessities – 61 – K

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A61K 38/54 (2006.01) A61K 9/14 (2006.01) A61K 38/46 (2006.01)

Patent

CA 2633238

The present invention comprises methods and compositions for the reduction of oxalate in humans. For example, the invention provides methods and compositions for the delivery of one or more oxalate-reducing enzymes embedded in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions including, but not limited to, hyperoxaluria, absorptive hyperoxaluria, enteric hyperoxaluria, primary hyperoxaluria, idiopathic calcium oxalate kidney stone disease (urolithiasis), vulvodynia, oxalosis associated with end-stage renal disease, cardiac conductance disorders, inflammatory bowel disease, Crohn's disease, ulcerative colitis, and patients who have undergone gastrointestinal surgery and bariatric surgery (surgery for obesity), and/or who have undergone antibiotic treatment.

La présente invention concerne des méthodes et des compositions pour la réduction d'oxalate chez les humains. Par exemple, l'invention concerne des méthodes et des compositions pour l'administration d'une ou de plusieurs enzymes de réduction d'oxalate incorporées dans des compositions particulaires. Les compositions de la présente invention peuvent être utilisées dans des méthodes de traitement ou de prévention de maladies liées à l'oxalate comprenant notamment, mais pas exclusivement, l'hyperoxalurie, l'hyperoxalurie absorptive, l'hyperoxalurie entérique, l'hyperoxalurie primaire, le calcul rénal d'oxalate de calcium idiopathique (urolithiase), la vulvodynie, l'oxalose associée à l'insuffisance rénale terminale, les troubles de la conduction cardiaque, la maladie intestinale inflammatoire, la maladie de Crohn, la rectocolite hémorragique, et chez des patients ayant subi une chirurgie gastro-intestinale et une chirurgie bariatrique (chirurgie de l'obésité), et/ou ayant subi un traitement antibiotique.

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