Compositions and methods for pace 4 and 4.1 gene and...

Details Compositions and methods for pace 4 and 4.1 gene and... Compositions and methods for pace 4 and 4.1 gene and...

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 38/48 (2006.01) A61K 38/57 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2131549

2131549 9318159 PCTABS00025 Compositions and methods are provided for endopeptidases and their production, and for enhanced efficiencies of processing heterologous precursor polypeptides to mature polypeptides. These compositions and methods utilize recombinant PACE 4 and 4.1, mammalian endopeptidases that are specific for dibasic amino acid sites. Therapeutic compositions and methods employing PACE 4 or 4.1 or their inhibitors are also provided.

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