Compositions and methods for packaging of alphavirus vectors

Details Compositions and methods for packaging of alphavirus vectors Compositions and methods for packaging of alphavirus vectors

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) C12N 5/10 (2006.01) C12N 7/00 (2006.01) C12N 15/40 (2006.01) C07K 14/18 (2006.01)

Patent

CA 2719413

Nucleic acid molecules are provided comprising a nucleic acid sequence which encodes, in order, an alphavirus capsid, a signal peptide, and an alphavirus El or E2 glycoprotein. Also provided are vectors encoding such nucleic acid molecules, and use of such vectors or expression cassettes to generate recombinant alphavirus particles and alphavirus packaging cell lines. In addition, modified alphavirus vector constructs are provided that permit reduced transgene expression during vector packaging, as well as methods of using such vector constructs for the production of alphavirus vector particles.

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