Compositions and methods for ph targeted drug delivery

Details Compositions and methods for ph targeted drug delivery Compositions and methods for ph targeted drug delivery

A - Human Necessities

61

K

A61K 9/51 (2006.01) A61K 31/4745 (2006.01) C08F 12/12 (2006.01) C08F 12/20 (2006.01) C08F 297/02 (2006.01)

Patent

CA 2699184

The invention provides compositions and methods for the targeted, in particular, pH targeted, delivery of pharmaceutically active agents in mammals. The compositions comprise pH sensitive diblock copolymers, which permit the release of the pharmaceutically active agent when exposed to an environment having a particular pH greater. The compositions are particularly useful for the oral delivery of water insoluble pharmaceutically active agents.

La présente invention concerne des compositions et des procédés d'administration ciblée, notamment ciblée par rapport au pH, d'agents pharmaceutiquement actifs à des mammifères. Ces compositions comprennent des copolymères à deux séquences sensibles au pH qui permettent la libération de l'agent pharmaceutiquement actif lorsqu'ils sont exposés à un environnement présentant un pH particulier plus élevé. Les compositions selon cette invention sont notamment utilisées pour l'administration par voie orale d'agents pharmaceutiquement actifs qui sont insolubles dans l'eau.

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