Compositions and methods for preferential distribution of...

Details Compositions and methods for preferential distribution of... Compositions and methods for preferential distribution of...

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 33/06 (2006.01) A61K 47/10 (2006.01)

Patent

CA 2756636

Compositions are provided for preferential distribution of active agents to injury sites. Such compositions may comprise a ligand with hydrophilic properties and one or more active agents, such as compounds comprising hydrophilic metal ions. Because the delivery ligand and the active agent are specifically selected so the interactions between them are mainly of an ionic nature so that binding of the active agent to the delivery ligand and release of the active agent into the target site are not dependent on enzymatic activity. Methods of using such compositions are also disclosed.

L'invention concerne des compositions conçues pour l'administration préférentielle d'agents actifs au niveau de sites de blessure. Ces compositions peuvent comprendre un ligand présentant des propriétés hydrophiles ainsi qu'un ou plusieurs agents actifs tels que des composés comportant des ions métalliques hydrophiles. Le ligand d'administration et l'agent actif sont sélectionnés spécifiquement de manière que les interactions entre eux soient principalement de nature ionique, de sorte que la liaison de l'agent actif avec le ligand d'administration et la libération de l'agent actif au niveau du site cible ne dépendent pas de l'activité enzymatique. Cette invention se rapporte en outre à des procédés d'utilisation de ces composés.

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