Compositions and methods for preparation of poorly water...

A - Human Necessities – 61 – K

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Details

A61K 9/51 (2006.01) A61K 31/337 (2006.01) A61K 47/42 (2006.01) A61K 9/00 (2006.01) A61K 9/19 (2006.01)

Patent

CA 2620389

The present invention provides stable pharmaceutical compositions of poorly water soluble pharmaceutical agents and stabilizing agents which function to increase stability of the compositions. The use of stabilizing agents provide extended stability of nanoparticle suspensions and other formulations of poorly water soluble pharmaceutical agents such as docetaxel under certain conditions, for example upon dilution for administration.

L'invention concerne des compositions pharmaceutiques stables d'agents pharmaceutiques faiblement solubles dans l'eau, et des stabilisateurs permettant d'accroître la stabilité de ces compositions. L'utilisation ce ces stabilisateurs confère une stabilité prolongée aux suspensions de nanoparticules et à d'autres préparations d'agents pharmaceutiques faiblement solubles dans l'eau, tels que le docetaxel, dans certaines conditions, par exemple après leur dilution pour l'administration.

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