Compositions and methods for preventing and treating...

A - Human Necessities – 61 – K

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Details

A61K 31/497 (2006.01) A61K 31/7076 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2718152

A method for prophylaxis and/or treatment of mucositis comprising the steps of providing a therapeutically effective amount of a composition comprising either (1) at least one compound selected from the group consisting of 5-[2-pyrazinyl]-4-methyl--1,2-3-thione or an analogue, derivative, metabolite, prodrug, solvate or a pharmaceutically acceptable salt thereof; or (2) a cytokinin compound; and administering the composition to a subject in need of such treatment. Also provided are pharmaceutical compositions comprising 5-[2-pyrazinyl]-4-methyl-1,2-3- thione and/or a cytokinin compound and use of these compositions in the preparation of a medicament for the treatment and/or prophylaxis of mucositis. The cytokinin compound may be selected from, but is not limited to N6-isopentenyl adenosine and N6-benzyl adenosine. The compositions may further comprise a chemotherapeutic agent, such as cisplatin. Further provided are methods and compositions for reducing and/or preventing weight loss in subjects undergoing cancer treatment.

L'invention porte sur un procédé pour la prophylaxie et/ou le traitement de l'inflammation d'une muqueuse comprenant les étapes consistant à se procurer une quantité thérapeutiquement efficace d'une composition comprenant soit (1) au moins un composé choisi dans le groupe constitué par le 5-[2-pyrazinyl]-4-méthyl-1,2-3-thione ou un analogue, dérivé, métabolite, promédicament, solvate ou sel pharmaceutiquement acceptable de celui-ci; soit (2) un composé cytokinine; et à administrer la composition à un sujet nécessitant un tel traitement. L'invention porte également sur des compositions pharmaceutiques comprenant le 5-[2-pyrazinyl]-4-méthyl-1,2-3-thione et/ou un composé cytokinine et sur une utilisation de ces compositions dans la préparation d'un médicament pour le traitement et/ou la prophylaxie de l'inflammation d'une muqueuse. Le composé cytokinine peut être sélectionné parmi, mais sans y être limité, la N6-isopentényl adénosine et la N6-benzyl adénosine. Les compositions peuvent en outre comprendre un agent chimiothérapeutique, tel que la cisplatine. L'invention porte en outre sur des procédés et des compositions pour réduire et/ou prévenir la perte de poids dans des sujets subissant un traitement du cancer.

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