Compositions and methods for priming monocytic dendritic...

C - Chemistry – Metallurgy – 12 – N

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C12N 5/0784 (2010.01) C12N 5/0783 (2010.01) A61K 35/12 (2006.01) A61K 35/14 (2006.01) A61K 38/19 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2459713

The present invention provides compositions and methods for inducing maturation of immature dendritic cells (DC) and for priming those cells for inducing a type 1 immune response. The present invention also provides dendritic cell populations useful for activating and for preparing T cells polarized towards production of type 1 cytokines and/or a type 1 response. Similarly, activated, polarized T cell populations, and methods of making the same are provided.

La présente invention concerne des compositions et des procédés visant à induire la maturation des cellules dendritiques (DC) immature et à amorcer ces cellules pour l'induction d'une réponse immunitaire de type 1. L'invention concerne également des populations de cellules dendritiques convenant à l'activation et la préparation de lymphocytes T orientés vers la production de cytokines de type 1 et/ou une réponse de type 1. De la même façon, l'invention concerne aussi des populations de lymphocytes T orientés et activés et des procédés d'obtention correspondant.

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