Compositions and methods for producing and using homogeneous...

A - Human Necessities – 61 – K

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A61K 35/30 (2006.01) A01K 67/027 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2176216

Methods of treating individuals suspected of suffering from diseases, conditions or disorders of the Central Nervous System which comprise implanting stable, homogeneous post-mitotic human neurons into the individual's brain are disclosed. Methods of treating individuals suspected of suffering from injuries, diseases, conditions or disorders characterized by nerve damage which comprise implanting stable, homogeneous post-mitotic human neurons at or near a site of said nerve damage. Pharmaceutical compositions comprising stable, homogeneous post-mitotic human neurons and a pharmaceutically acceptable medium are disclosed. Methods of generating non-human animal models of human CNS diseases, conditions or disorders which comprise implanting stable, homogeneous post-mitotic human neurons into the brain of a non-human animal are disclosed. Non-human animals comprising stable, homogeneous post-mitotic human neurons implanted in their brain are disclosed.

Méthodes de traitement de personnes présentant des affections, des états pathologiques ou des troubles du système nerveux central (SNC), consistant à leur implanter dans le cerveau des neurones humains post-mitotiques stables et homogènes. Méthodes de traitement de personnes souffrant de lésions, d'affections, d'états pathologiques ou de troubles résultant de dommages aux nerfs, consistant à implanter sur le site du dommage, ou à proximité, des neurones humains post-mitotiques stables et homogènes. Compositions pharmaceutiques à base de neurones humains post-mitotiques stables et homogènes et excipient pharmacocompatible associé. Méthodes d'élaboration de modèles animaux non humains d'affections, d'états pathologiques et de troubles du SNC humain, consistant à implanter dans le cerveau d'animaux non humains des neurones humains post-mitotiques stables et homogènes. Animaux non humains dans le cerveau desquels ont été implantés des neurones humains post-mitotiques stables et homogènes.

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