Compositions and methods for producing recombinant proteins

Details Compositions and methods for producing recombinant proteins Compositions and methods for producing recombinant proteins

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/32 (2006.01) C07K 19/00 (2006.01) C12N 15/31 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2591992

A class of integral membrane proteins, referred to as Mistic polypeptides, their variants, fusion proteins including a Mistic polypeptide domain, and nucleic acid molecules encoding Mistic polypeptides and Mistic fusion proteins are disclosed herein. Also described are methods of using Mistic polypeptides and Mistic fusion proteins to produce and/or isolate recombinant proteins (including without limitation classes of eukaryotic proteins that have previously been intractable to recombinant bacterial expression, such as, eukaryotic integral membrane proteins).

L'invention concerne une catégorie de protéines à membrane intégrale, connues sous l'appellation de polypeptides Mistic, leurs variantes, des protéines hybrides contenant un domaine de polypeptide Mistic, ainsi que des molécules d'acide nucléique codant des polypeptides Mistic et des protéines hybrides Mistic. L'invention concerne également des procédés permettant d'utiliser des polypeptides Mistic et des protéines hybrides Mistic pour produire et/ou isoler des protéines recombinées (comprenant sans restriction des catégories de protéines eucaryotes qui ont été réfractaires antérieurement à l'expression bactérienne recombinée, comme des protéines à membrane intégrale eucaryote).

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