A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/37 (2006.01) A61K 47/48 (2006.01) A61P 7/04 (2006.01) C07K 16/30 (2006.01) C07K 19/00 (2006.01)
Patent
CA 2469087
The present invention relates generally to methods and compositions for targeting, delivering, and activating platelet-dependent vascular occlusion agents. In particular, fusion proteins carrying platelet binding agents are targeted to hyperplastic cells or tissues, such as the vasculature of solid tumor masses; the platelet binding agent then binds and activates platelets, which in turn bind and activate other platelets. This process results in the formation of a platelet-mediated thrombus-causing vessel occlusion.
L'invention concerne généralement des procédés et des compositions destinés à cibler, administrer et à activer des agents d'occlusion vasculaire utilisant l'activation plaquettaire. En particulier, des protéines de fusion portant des agents de liaison aux plaquettes sont ciblées sur des cellules ou des tissus hyperplasiques, notamment le système vasculaire de masses de tumeur solide, l'agent de liaison aux plaquettes se liant alors aux plaquettes et les activant, qui à leur tour se lient à d'autres plaquettes et les activent. Ce procédé résulte en la formation d'un thrombus par activation des plaquettes, provoquant l'occlusion de vaisseau.
Noujaim Antoine
Person Roland H.
Stewart Michael W.
Haugen J. Jay
Virexx Medical Corp.
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