Compositions and methods for producing vascular occlusion

Details Compositions and methods for producing vascular occlusion Compositions and methods for producing vascular occlusion

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 31/727 (2006.01) A61K 38/36 (2006.01) A61K 38/48 (2006.01) A61K 47/42 (2006.01) A61P 7/04 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2348781

The present invention relates generally to methods and compositions for targeting, delivering, and activating platelet-dependent vascular occlusion agents. In particular, antibodies carrying platelet binding agents are targeted to hyperplastic cells or tissues, such as the vasculature of solid tumor masses; the platelet binding agent then binds and activates platelets, which in turn bind and activate other platelets. This process results in the formation of a platelet-mediated thrombus-causing vessel occlusion.

L'invention porte sur d'une manière générale sur des méthodes et composition assurant le ciblage, la délivrance et l'activation d'agents d'occlusions vasculaire liés aux plaquettes. En particulier les anticorps porteurs d'agents liant les plaquettes sont dirigés vers des cellules ou des tissus hyperplastiques tels que des masses tumorales solides. Lesdits agents fixent et activent certaines plaquettes qui à leur tour en fixent et activent d'autres. Ce processus aboutit à la formation d'un thrombus induit par les plaquettes, qui provoque l'occlusion des vaisseaux.

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