Compositions and methods for producing vascular occlusion...

Details Compositions and methods for producing vascular occlusion... Compositions and methods for producing vascular occlusion...

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 31/16 (2006.01) A61K 38/36 (2006.01) A61K 38/37 (2006.01) A61K 47/48 (2006.01) A61L 31/04 (2006.01) A61L 31/16 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2459794

The present invention relates generally to methods and compositions for targeting and delivering solid-phase platelet-dependent vascular occlusion agents. In particular, particles or coils or stents coated with platelet binding agents are directed to target vasculature, such as the vasculature of solid tumor masses or AV-malformations or aneurysms or endoleaks; the solid- phase agent then binds and activates platelets, which in turn bind and activate other platelets. This process results in the rapid formation of a platelet-mediated thrombus about the solid-phase agent, causing vessel occlusion.

La présente invention porte en général sur des procédés et des compositions permettant de cibler et d'administrer des agents d'occlusion vasculaire en phase solide associés aux plaquettes. L'invention porte notamment sur des particules ou des enroulements ou des stents enrobés d'agents de liaison plaquettaire qui sont dirigés sur un système vasculaire cible tel que celui des masses tumorales solides ou des malformations ou anévrismes artérioveineux ou des fuites endogènes. L'agent en phase solide se lie ensuite aux plaquettes et les active, plaquettes qui, à leur tour, se lient à d'autres plaquettes et les activent. Ce processus entraîne la formation rapide d'un thrombus, induit par les plaquettes, autour de l'agent en phase solide provoquant l'occlusion vasculaire.

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