A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/765 (2006.01) A61K 38/39 (2006.01) A61L 31/06 (2006.01) A61L 31/14 (2006.01) A61L 31/16 (2006.01) A61P 7/04 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2706742
The present invention relates generally to methods and compositions for targeting and delivering solid-phase platelet-dependent vascular occlusion agents. In particular, particles or coils or stents coated with platelet binding agents are directed to target vasculature, such as the vasculature of solid tumor masses or AV-malformations or aneurysms or endoleaks; the solid-phase agent then binds and activates platelets, which in turn bind and activate other platelets. This process results in the rapid formation of a platelet-mediated thrombus about the solid-phase agent causing vessel occlusion.
La présente invention porte d'une manière générale sur des procédés et des compositions pour cibler et distribuer des agents d'occlusion vasculaire dépendant des plaquettes en phase solide. En particulier, des particules ou enroulements ou stents revêtus par des agents de liaison aux plaquettes sont dirigés sur un système vasculaire cible, tel que le système vasculaire de masses tumorales solides ou des malformations artérioveineuses ou des anévrismes ou des endofuites ; l'agent en phase solide se lie ensuite et active des plaquettes, lesquelles à leur tour se lient et activent d'autres plaquettes. Ce procédé conduit à la formation rapide d'un thrombus à médiation par les plaquettes autour de l'agent en phase solide provoquant une occlusion de vaisseau.
Griffith Irwin J.
Noujaim Antoine
Person Roland H.
Stewart Michael W.
Tiege Paul B.
Burnet Duckworth & Palmer Llp
Imbiotechnologies Ltd.
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