A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/03 (2006.01) A61K 38/10 (2006.01) A61K 38/22 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2474203
The invention provides methods of using polypeptide compounds based on the structures of insect peptides of the adipokinetic hormone family in humans for a variety of purposes, including mobilization of lipids and glycogen, inhibition of protein, lipid, and RNA synthesis, and enhancement of muscle contractility. The compositions and methods described in the application are useful, for example, for modulating human body weight, inducing weight loss, and alleviating glycogen storage disorders. The invention also includes screening methods for identifying other compounds having similar activities in humans.
L'invention concerne des procédés d'utilisation de composés de polypeptides basés sur des structures des de peptides d'insectes de la famille des hormones adipocinétiques chez des humains à des fins variées. Ledit procédé comprend les étapes de mobilisation de lipides et de glycogène, d'inhibition des protéines, des lipides et de synthèse d'ARN, ainsi que l'amélioration de la contractilité des muscles. Lesdites compositions et procédés de l'invention sont utiles, par exemple, pour moduler le poids d'un corps humain, induire une perte de poids, et atténuer les troubles du stockage de glycogène. L'invention concerne également des procédés de criblage destinés à identifier d'autres composés présentant des activités similaires chez des humains.
Schacter Bernice Z.
Schacter Lee P.
Blm Group
Fetherstonhaugh & Co.
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