C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61P 9/10 (2006.01) C07K 5/083 (2006.01) C07K 5/103 (2006.01)
Patent
CA 2470503
Methods, compositions and devices are disclosed for use in growing new blood vessels to restore or improve blood flow to ischemic tissues and organs of the body. Compositions comprising IGD peptides, particularly GGIGDGG, are able to induce migration in human endothelial cells and promote vessel formation in an in vitro model assay system.
L'invention concerne des procédés, des compositions et des dispositifs destinés à être utilisés pour faire croître de nouveaux vaisseaux sanguins afin de restaurer ou d'améliorer l'écoulement sanguin dans des tissus et des organes ischémiques du corps. Ces compositions comprennent des peptides IGD, plus spécifiquement GGIGDGG, et permettent d'induire la migration dans des cellules endothéliales humaines et de promouvoir la formation de vaisseaux dans un système d'essai modèle in vitro.
Akella Rama
Ranieri John
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Centerpulse Biologics Inc.
Zimmer Orthobiologics Inc.
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