Compositions and methods for promoting tissue repair using...

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/16 (2006.01) A61K 38/17 (2006.01)

Patent

CA 2347204

The invention relates to methods and compositions for the promotion of tissue repair. Specifically, compositions comprising heat shock proteins, including gp96, hsp90, and hsp70, uncomplexed or complexed noncovalently with antigenic molecules, are disclosed. Therapeutic methods for administering the hsp- containing compositions are disclosed. The disclosed methods are useful for promoting repair of tissues that were disrupted by a variety of causes including trauma (e.g., surgery, injury or burns) or disease or disorder (e.g., atherosclerosis and multiple sclerosis).

L'invention concerne des méthodes et des compositions favorisant la réparation tissulaire. Ces compositions comprennent, en particulier, des protéines de choc thermique (hsp), notamment gp96, hsp90, et hsp70, complexées ou non complexées, de manière non covalente, avec des molécules antigèniques. L'invention concerne également des méthodes thérapeutiques consistant à administrer les compositions contenant hsp. Ces méthodes sont utiles pour favoriser la réparation des tissus ayant été endommagés par un trauma (par exemple une chirurgie, une blessure ou des brûlures), une maladie ou un trouble (par exemple, l'athérosclérose et la sclérose en plaques).

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