C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0797 (2010.01) C12N 5/071 (2010.01) C12N 5/0789 (2010.01) A01N 1/02 (2006.01) A61K 35/30 (2006.01) C12N 1/04 (2006.01)
Patent
CA 2547827
Compositions and methods for the culturing, propagation, cryopreservation and manipulation of neural progenitor cells (NPC) and pluripotent stem cells (PSC) are provided. The cells exhibit rapid doubling times and can be maintained in vitro for extended periods. Also provided is a method of propagating neural progenitor cells, and a method of transplanting human NPC and/or PSC to a host. The cells can be genetically modified to express a therapeutic agent prior to the transplanting.
La présente invention concerne des compositions et des procédés de culture, propagation, cryopréservation et manipulation de cellules progénitrices neuronales (NPC) et de cellules souches multipotentes (PSC). Les cellules présentent des durées de doublement courtes et peuvent être conservées <i>in vitro</i> sur de grandes durées. L'invention concerne également un procédé de propagation de cellules progénitrices neuronales et un procédé de transplantation de cellules progénitrices neuronales (NPC) et/ou de cellules souches multipotentes (PSC) sur un hôte. Lesdites cellules peuvent être modifiées génétiquement afin d'exprimer un agent thérapeutique avant transplantation.
Catholic Healthcare West
Celavie Biosciences Llc
Sim & Mcburney
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