C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/06 (2006.01) C07B 59/00 (2006.01) C07C 227/20 (2006.01) C07C 237/06 (2006.01) C07C 323/58 (2006.01) C07D 209/20 (2006.01) C07K 1/14 (2006.01) C12N 1/12 (2006.01) C12N 1/20 (2006.01) C12N 5/02 (2006.01) C12P 13/04 (2006.01) C12P 13/12 (2006.01) C12P 13/14 (2006.01) C12P 21/00 (2006.01) C12Q 1/04 (2006.01) G01N 24/08 (2006.01) G01N 33/534 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01) G06F 17/50 (2006.01)
Patent
CA 2129904
2129904 9418339 PCTABS00033 A method for determining three-dimensional structural information of a protein involves producing the protein in a form substantially labeled with 13C or 15N or both or substantially labeled with 15N and 13C and partially labeled with 2H and subjecting the protein to nuclear magnetic resonance spectroscopic analysis. The isotopically labeled protein is produced by a method which involves producing a substantially labeled microbial protein hydrolysate, subjecting the protein hydrolysate to cation exchange chromatography to produce a partially purified labeled amino acid mixture, subjecting the partially purified labeled amino acid mixture to anion exchange chromatography to produce a purified labeled amino acid mixture and supplementing the purified labeled amino acid mixture with isotopically labeled cysteine and optionally with isotopically labeled glutamine and asparagine.
Martek Biosciences Corporation
Osler Hoskin & Harcourt Llp
LandOfFree
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