Compositions and methods for reducing blood and fluid loss...

A - Human Necessities – 61 – L

Patent

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A61L 26/00 (2006.01)

Patent

CA 2449436

The invention described herein relates to methods for reducing and/or stopping bleeding or fluid loss from open wound, denuded tissue, or burned skin, comprising the step of applying to the open wound, denuded tissue or burned skin a gel-fonning composition comprising at least one of the following compositions: a polyacry1ic acid having the structural formula [CH2=CHCO2H]n, where n is between 10,000 and 70,000; a polyacrylic acid and a desiccated water soluble organic or inorganic base; polyacrylic acid and a desiccated poorly soluble basic salt, and a polyvinyl alcohol having the structural formula of [CH2=CHOH]n, where n is between 15,000 and 150,000. When the gel- forming composition is applied to the open wound, denuded tissue, or burned skin, its ions react therein in the presence of water from blood or body fluid therein to form an aqueous gel or mucilage having sufficient viscosity and adhesiveness to cover and adhere to the open wound, denuded tissue, or burned skin so that bleeding or fluid loss is thereby reduced and/or stopped.

L'invention concerne des procédés permettant de réduire et/ou d'arrêter le saignement ou la perte de liquide d'une blessure ouverte, d'un tissu découvert ou d'une peau brûlée. Ces procédés consistent à appliquer sur la plaie ouverte, le tissu découvert ou la peau brûlée, une composition formant un gel, cette composition contenant au moins une des compositions suivantes: un acide polyacrylique de formule structurelle [CH¿2?=CHCO¿2?H]¿n?, dans laquelle n est compris entre 10 000 et 70 000; un acide polyacrylique et une base organique ou inorganique hydrosoluble déshydratée; un acide polyacrylique et un sel basique faiblement soluble déshydraté, et un alcool polyvinyle de formule structurelle [CH¿2?=CHOH]¿n?, dans laquelle n est compris entre 15 000 et 150 000. Lorsque la composition formant un gel est appliquée sur la plaie ouverte, le tissu découvert ou la peau brûlée, ses ions réagissent à la présence d'eau dans le sang ou dans le liquide organique pour former un gel aqueux ou un mucilage présentant une viscosité et une adhérence suffisantes pour recouvrir la plaie ouverte, le tissu découvert ou la peau brûlée et y adhérer, de sorte à réduire et/ou arrêter le saignement ou la perte de liquide.

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