Compositions and methods for reducing respiratory depression...

Details Compositions and methods for reducing respiratory depression... Compositions and methods for reducing respiratory depression...

A - Human Necessities

61

K

A61K 31/495 (2006.01) A61K 31/4468 (2006.01) A61K 31/454 (2006.01) A61K 38/08 (2006.01) A61K 45/00 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2294924

A method of reducing, treating or preventing drug-mediated respiratory depression, muscle rigidity, or nausea/vomiting in an animal, incident to the administration to said animal of a mixed delta/mu opioid agonist or a respiratory depression-mediating drug, comprising administering to the animal receiving said drug an effective amount of a delta receptor agonist compound. The figure shows the effect of the positive isomer of the delta agonist BW373U86 on analgesia and respiratory depression induced by the mu agonist, alfenta. The delta agonist compound may comprise a compound of formula (I), wherein the variables of Ar, G, Z, R2, R3, R4, R5, R6 and R7 are herein described in the description.

Méthode permettant d'atténuer, de traiter ou d'éviter la dépression respiratoire, la rigidité musculaire, les nausées et/ou les vomissements d'origine iatrogène chez un mammifère, dus à l'administration audit mammifère d'un mélange d'agonistes opioïdes delta/mu ou d'un médicament entraînant une dépression respiratoire. La méthode consiste à administrer au mammifère recevant ledit médicament une quantité efficace d'un composé renfermant un agoniste des récepteurs delta. La figure montre l'effet de l'isomère positif de l'agoniste delta BW373U86 sur l'analgésie et sur la dépression respiratoire induite par l'agoniste mu, l'alfenta. Le composé agoniste delta peut renfermer un composé de formule (I), dans laquelle les variables Ar, G, Z, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿ et R?7¿ sont telles que définies dans la description.

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