A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 31/436 (2006.01) A61M 11/00 (2006.01) A61M 25/00 (2006.01)
Patent
CA 2524639
The present invention describes the application of sirolimus and analogs of sirolimus to treat wound healing and reduce scar tissue formation. Also contemplated are non-sirolimus compounds believed to interact with the mTOR protein that have similar effects. Specifically, various medium are contemplated to create, for example, microparticles, foams, gels, sprays and bioadhesives that may be administered during surgical procedures involving either open or closed surgical site. Coating medical devices for long-term implantation is contemplated as one method of use of the above compositions.
La présente invention se rapporte à l'application du sirolimus ou d'analogues du sirolimus pour traiter des plaies et diminuer la formation de cicatrices. L'invention concerne également des composés autres que le sirolimus, dont on estime qu'ils interagissent avec la protéine mTOR et présentent une action similaire. Plus particulièrement, on décrit divers moyens qui permettent de produire, par exemple, des microparticules, des mousses, des gels, des eaux pulvérisées et des bioadhésifs pouvant être administrés lors d'interventions chirurgicales impliquant un champ opératoire ouvert ou fermé. Une des applications des compositions de l'invention se rapporte à son utilisation comme revêtement d'instruments médicaux destinés à une greffe à long terme.
Fischell Robert E.
Fischell Sarah T.
Fischell Tim A.
Waldorf Clayton Mackenzie
Afmedica Inc.
Smart & Biggar
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