Compositions and methods for reducing the risk of epileptic...

Details Compositions and methods for reducing the risk of epileptic... Compositions and methods for reducing the risk of epileptic...

C - Chemistry, Metallurgy

07

D

C07D 213/02 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2535483

The present invention relates to compounds and compositions useful for reducing the risk of epileptic occurrences and/or for alleviating epileptic phenomena in patients. In accordance with the invention, the compounds and compositions have at least the following two components: a) vitamin B6-based component selected from pyridoxal, pyridoxamine, pyridoxine, their pharmaceutically acceptable functional derivatives and salts; and b) at least one antiepileptic drug (AED) or anticonvulsive, neuroprotective drug or nootrope compound or moiety. The invention further relates to methods for preventing epileptic episodes and for alleviating epileptic episodes, as well as methods for reducing side effects of antiepileptic drugs.

La présente invention porte sur des composés et sur des compositions utiles pour réduire les risques d'apparition de crises épileptiques et/ou pour atténuer le phénomène épileptique chez des patients. Selon cette invention, les composés et les compositions possèdent au moins les deux composants suivants : a) un composant à base de vitamine B6 sélectionné parmi pyridoxal, pyridoxamine, pyridoxine, et leurs dérivés fonctionnels et leurs sels acceptables d'un point de vue pharmaceutique ; et b) au moins un médicament anti-épileptique (AED) ou un médicament anti-convulsif, neuroprotecteur ou un composé nootrope ou une fraction de celui-ci. L'invention porte également sur des procédés visant à prévenir les crises épileptiques et à les atténuer, ainsi que sur des procédés visant à réduire les effets secondaires des médicaments anti-épileptiques.

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