A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/706 (2006.01) A61K 31/16 (2006.01) A61K 31/166 (2006.01) A61K 31/167 (2006.01) A61K 31/19 (2006.01) A61K 31/192 (2006.01) A61K 31/336 (2006.01) A61K 31/4406 (2006.01) A61K 38/12 (2006.01) A61K 38/15 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) C07H 19/06 (2006.01)
Patent
CA 2443560
Compositions and methods are provided for treating diseases associated with aberrant silencing of gene expression such as cancer by reestablishing the gene expression through inhibition of DNA hypomethylation and histone deacetylase. The method comprises: administering to a patient suffering from the disease a therapeutically effective amount of a DNA methylation inhibitor such as a cysteine analog such as decitabine, in combination with an effective amount of histone deacetylase inhibitor such as hydroxamic acid, cylcic peptide, benzamide, butyrate, and depudecin.
L'invention concerne des compositions et des procédés permettant de traiter des maladies associées à l'extinction aberrante de l'expression génique, par exemple le cancer, par le rétablissement de l'expression génique par le biais de l'inhibition de l'hypométhylation et de la histone désacétylase de l'ADN. Le procédé consiste à administrer au malade concerné une dose thérapeutiquement efficace d'un inhibiteur de la méthylation de l'ADN, par exemple un analogue de la cystéine tel que décitabine, en combinaison avec une dose efficace d'un inhibiteur de la histone désacétylase, tel que acide hydroxamique, peptide cyclique, benzamide, butyrate et dépudécin.
Dimartino Jorge
Fetherstonhaugh & Co.
Supergen Inc.
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